One of the great things about visiting Santiago is that it's relatively difficult to get lost. With the Andes always to the east and the wide variety of landmarks, such as the two iconic hills and a series of statues, fountains and other easily-recognizable buildings, you can orient yourself and learn a bit about the city at the same time.
San Pablo 967 Interior
Vergara and Av. 21 de Mayo
Avenida Libertador Bernardo O'Higgins 1091
National Monument and site for social events...
Calle Nueva York
Catedral y Monjitas
José Victorino Lastarria 305 y 307