Opened in the Casa Salazar in 1992, this museum traces the history of the city from the time of the Taíno peoples to the present. Interactive displays help visitors orient themselves and locate other attractions. The museum has a conservation laboratory, library, souvenir-and-gift shop, cafeteria, and conference facilities.
Casa Salazar ranks close to the top of Ponce's architectural treasures. Built in 1911, it combines neoclassical and Moorish details, while displaying much that is typical of the Ponce decorative style: stained-glass windows, mosaics, pressed-tin ceilings, fixed jalousies, wood or iron columns, porch balconies, interior patios, and the use of doors as windows.