Venustiano Carranza 290
Puerto Vallarta, Mexico
This is the largest and most popular of all of the gay clubs in PV. Club Manana isn't strictly a gay bar, plenty of gay-friendly straight people enjoy the high energy and great dance floor too. Things don't really start hopping until about midnight, but there's always something entertaining happening here. Check the calendar for the various shows and performances during the week. The drag show is great fun.
Drinks and the cover charge is a bit higher than other locations but you'll enjoy the friendliness of the crowd. Do use common sense and keep an eye on your personal belongings.